Ozena: Tuberculosis of the Nose, circa 1870.The dreaded infection ‘Ozena’ was an ailment of much prominence in the pre-antibiotic era because it accompanied many infectious diseases of the nose. The infection of the nasal cavities resulted in a foul nasal discharge & a fetid breath. Ozena is mainly seen today as a marked degeneration of the nasal mucosa. This occurs most commonly as a hereditary malady but is also associated with the over use of nasal sprays & drops.

rhino scleroma
Is a chronic granulomatous bacterial disease of the nose that can sometimes infect the upper respiratory tract.
H. Riffarth in Berlincopperplate engravings
Photogravure of rhinoscleroma from Wolkowitsch.

Klebsiella ozaenae

  • General information

    • the following information is not yet verified
      K. ozaenae and K. rhinoscleromais are associated with chronic diseases of the upper airways: ozena and rhinoscleroma.

      Family: Enterobacteriaceae
      K. pneumoniae subsp pneumoniae
      K. pneumoniae subsp. ozaenae
      K. pneumoniae subsp. rhinoscleromatis

      Clinical significance
      - K. ozaenae
      Occurs in ozena (a chronic disease of the nose characterized by foul smelling nasal discharge and atrophy of nasal structures) and other chronic diseases of the respiratory tract

      - K. rhinoscleromatis
      Causes a slowly progressing granulomatous disease of the nasal mucous membrane (rhinoscleroma)

  • Gram stain

    • the following information is not yet verified
      Gram negative straight rods,


  • Culture characteristics

    • the following information is not yet verified

      Facultative anaerobic

      They grow more slowly, yielding voluminous, rounded, very mucoid, translucent and confluent colonies in 48 hours.

      McConkey growth

      BBAØ growth

  • Characteristics

  • References

    • James Versalovic et al.(2011) Manual of Clinical Microbiology 10th Edition

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