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Aggregatibacter aphrophilus

  • General information


    • Taxonomy
      Family: Pasteurellaceae, previously: Haemophilus
      Genus: Aggregatibacter aphrophilus
      Formerly: Haemophilus aphrophilus

      Natural habitats
      Occur in the mouth and oropharynx of healthy individuals.

      It is a frequent member of the microflora of human dental plaque, particularly between the teeth and in the gingival pockets

      Clinical significance
      Has been isolated from blood, spinal fluid, peritoneum, pleura, wounds and jaw infections.

      Opportunistic pathogen occasionally implicated in subacute endocarditis, brain abscesses, sinusitis, arthritis and osteomyelitis often caused by dental treatments that cause a break of the oral mucosal barrier and a temporary bactereamia.

  • Gram stain

    • Gram negative short rods,

      0.4-0.6 x 1.5-1.7 µm,

      occasional filamentous forms. They may occur singly, in pairs or in small (big) clumps and show the tendency to bipolar staining.

      This gives an appearance of a "Morse code" of dots and dashes.

  • Culture characteristics

    • Facultative anaerobic

      5% CO2 improves the growth

      BA: colonies are high convex, granular, yellowish, opaque, 1.0-1.5 mm within 24 hours.

      Nonhemolytic

      Some isolates are V-factor dependent

      Broth: when grown in broth bacteria form granules at the bottom and up the sides of the tube (“tiny colonies”), while subsequent cultures become less adherent and exhibit uniform turbidity.

      McConkey: no growth

      BBAØ: growth

  • Characteristics

  • References

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