Tropheryma whipplei

  • General information

    • the following information is not yet verified
      Family: Cellulomonadaceae

      Natural habitat
      T. whipplei is all over in the environment, in sewage, plants and in human stools and saliva.

      Clinical significance
      1) classical Whipplei Disease (WD), which present with weight loss, diarrhea, and arthropathy in 75% of patients by the time of diagnosis.

      2) isolated infection of cardiac valves without classical WD

      3) asymptomatic carriers of T. whipplei. In these cases it is still unclear whether the asymptomatic carriers are only passing the agent through their stool.

      T. whipplei infection also results quite often in cardiac, lung, and central nervous systen (CNS) signs and symptoms, which can occur even in the absence of gastrointestinal manifestations.

      culture-negative endocarditis

  • Gram stain

    • the following information is not yet verified
      biopt heart valve,

      cells are gram positive and rod-shaped

      T. whipplei is a facultative, intracellular, rod-shaped, Gram positive, filamentous and aerobic bacterium , sized 0.5-2 µm.

  • Culture characteristics

    • the following information is not yet verified

      biopt heart valve,

      normaly culture-negative endocarditis

      16S rRNA PCR = Tropheryma whipplei

      aangetoond middels DNA

  • Characteristics

  • References

    • James Versalovic et al.(2011) Manual of Clinical Microbiology 10th Edition

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